Historically, RNA has been thought of as a messenger whose role is to translate information from DNA (the blueprint of a cell) and make proteins (which carry out the activities of a cell). There are many RNAs that do not make proteins, called “non-coding RNAs (ncRNA)”.
These ncRNAs are able to regulate essential processes and when altered cause disease. RNAs are more than merely messengers, but therapeutic targets with vast opportunities to improve outcomes for many diseases. NextRNA has developed an integrated drug discovery pipeline to identify and discover drugs for disease-causing ncRNAs.
For many non-coding RNAs (ncRNAs), their function depends on direct interactions with proteins. As a result, the fundamental biology and disease relevance of most ncRNAs can only be fully understood by defining their associated proteins. Traditional methods to define RNA-protein interactions were historically ineffective. NextRNA has developed and optimized a high-throughput screening platform to discover RNA-protein interactions and screen for molecules that disrupt these disease-relevant interactions. This platform is a key element in an integrated drug discovery pipeline that combines informatic tools, traditional methods, and novel approaches to develop transformative RNA-directed therapies.